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KMID : 0369820060360060401
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Jorunal of Korean Pharmaceutical Sciences
2006 Volume.36 No. 6 p.401 ~ p.403
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A Novel Organogel System Capable of Enhancing Skin Pnetration Characteristics of Acyclovir
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Lee Sang-kil
Choi Young-Wook
Lee Jae-Hwi
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Abstract
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Topical penetrations such as cream for Acyclovir(ACV), apotent anti-viral agent for the treatment of herpes simplex and herpes zoster, have been marketed in the world since 1993. However, the skin penetration rate of ACV from generic ceream formulations sold in Europe has been found to be lower than the original Zovirax® cream. In this study, we fomulated ACV into a novel organogel system and compared the skin penetration characteristics with Zovirax® cream. The rate and amount of skin penetration of ACV from the organogels were 6.3-fold greater than those obtained with Zovirax® at an ACV concentration of 5%. The solubilizing effect of oil phase and anti-nucleation effect exhibited by sodium alginate contained in water phase are most likelt attributed to enhanced ACV skin penetration property.
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KEYWORD
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Acyclovir, Organogel, Skin Pnetration
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